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In the first study, the authors reported the appearance of dying OLs expressing activated caspase 3 which was accompanied by a significant decrease in NogoA-positive mature OLs after 6 days of CPZ feeding at the dose of 0.3%, and they also claimed that apoptotic OLs were present not only in the corpus callosum but also in the cortex 2 days after the start of the CPZ diet, although they did not show the data (Hesse et al., 2010).The second and more recent study showed the loss of CC1-positive OLs in the corpus callosum as early as 2 days after CPZ exposure in the standardized CPZ model (Jhelum et al., 2020)

The most abundant anthocyanidins include delphinidin, cyanidin, petunidin, peonydin, malvidin, and pelargonidin [25]

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Protects organs under oxidative stress (e.g., liver, heart, brain)

Given that NOX and NOS activity in neutrophils and macrophages depend upon G6PD-derived NADPH and reduced glutathione (GSH) ( 2.1 G6PD and PPP function in neutrophils As the most common circulating blood leukocyte, neutrophils are crucial for monitoring pathogens and tissue damage

Selective suppression of M1 macrophages is involved in zinc inhibition of liver fibrosis in mice