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Correcting Cholinergic Deficits in Parkinsons Disease: Cotinine a Potential Therapeutic Agent The cholinergic system plays a broad role in controlling neurotransmitter release, reducing neuroinflammation, and promoting neuronal survival and synaptic plasticity in the brain

The results showed that the overall response rate was 91%, with a complete response rate of 73% and a partial response rate of 18%, indicating that this treatment plan has significant clinical efficacy [134]