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Autophagy-dependent cell death is considered as a regulated form of cell death that relies on the autophagic apparatus and generally adheres to the following criteria (1): elevated autophagy flux occurring simultaneously with cell death (2), reversibility of cell death when autophagy is inhibited through pharmacological or genetic means (3), dependence on at least two components of the autophagic process, and (4) absence of concurrent alternative forms of cell death (6)

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In contrast, tumors with low phosphorylated ERK expression may exhibit resistance (Huang et al., 2023[55])