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The SUSTAIN Phase III program then provided unequivocal evidence of superior HbA1c lowering, meaningful weight reduction, and, critically, cardiovascular risk mitigation, culminating in a 26% relative risk reduction in major adverse cardiovascular events in SUSTAIN-6

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Thus, based on the understanding of the role of the HGF/c-Met signaling pathway and the uniqueness of c-Met in HCC, more and more therapeutic strategies target c-Met and the interaction between c-Met and downstream signaling mediators instead of the interaction between HGF and c-Met because of the varying activation of c-Met

(2015) established that fluorescein isothiocyanate (FITC)-dextran of 4 kD freely diffused through the GVB, whereas FITC-dextran of 70 kD could not, whereas infection with Salmonella enterica disrupted GVB and promoted 70 kD FITC-dextran crossing GVB