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The safety and immunogenicity (type I IFN dependent responses) as well as the delivery efficacy of loaded immune adjuvants [poly(I:C)) in a proposed biomaterial matrix were further validated in canine veterinary models with cancer [121, 122]

Methods Forty-eight male Wistar albino rats (300350 g) were randomly allocated into four groups ( n = 12 each): C14, A14, C28, and A28

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