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Metformin treatment (72 h) induced a significant increase in early and late apoptotic HCT116 cells, when compared to vehicle control ( Figures 3B, D )

Specifically, research shows that Bifidobacterium adolescentis is a high GABA producer.[ref] Lactobacillus brevis DPC6108 and Lactobacillus rhamnosus are also probiotic strains that produce GABA.[ref][ref] A 2024 double blind placebo controlled trial found that a probiotic formulation of Lactobacillus brevis and Lactiplantibacillus plantarum reduced symptoms of depression and improved mood, but did not affect stress levels

In contrast, we found blood total glutathione (tGSH), reduced glutathione (GSH), GSH/GSSG, tGSH/GSSG, methionine, cysteine, S -adenosylmethionine (SAM)/SAH, vitamins (B9, B12, D, and E), and calcium concentrations were significantly decreased in ASD children relative to controls (Table 1 and Figs

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doi: 10.1038/bjc.2014.175