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These thalamic relays establish reciprocal circuits with the M1, forming a closed-loop circuit that integrates motor commands and nociceptive processing (53)

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J Renal Nutr 2001;11:67-72

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In the stress-sedentary model, researchers conducted pharmacodynamic assessments using endurance running, a nontraditional pharmacologic tool, and observed an ameliorative effect on neurexins- and neuroligin 1 expression and synaptic plasticity [54]