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Adding control features with known concentrations to samples before profiling, data transformation methods like centered log-transformation, and data normalization processes, including more recently created methods like empirical Bayes normalization, are some strategies for resolving compositionality (Quinn et al., 2019

[16] Galano A, Alvarez-Idaboy JR

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Disclosure of interest: FAM, KG, VR, MK, WNW, KB, PH have nothing to disclose Poster Session II - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P1005 - ESOC25-1187 PREVALENCE AND OUTCOME OF CEREBRAL MICROBLEEDS IN ANTIPHOSPHOLIPID SYNDROME Jonathan Naftali 1 , Rani Barnea 1 , Ruth Eliahou 1 , Tzippy Shochat 1 , Adi Wilf-Yarkoni 1 , Sivan Bloch 2 , Michael Findler 1 , Avi Leader 3 , Walid Saliba 2 , Eitan Auriel 1 1 Rabin medical center, Tel Aviv University, Petah Tikva, Israel, 2 Carmel medical center, Haifa, Israel, 3 Memorial Sloan Kettering Cancer Center, New-York, United States Background and Aims: Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by arterial and venous thrombosis

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