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The foremost priority is the design of large-scale, long-term randomized controlled trials incorporating histological endpoints as primary outcomes

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Male Sprague-Dawley rats 250+ g were obtained from Harlan Laboratories (CA, USA) for use in pharmacokinetic studies

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Ligand density, hydrophobicity, avidity, and length must all be considered and tuned for effective nanoparticle targeting [15,16]

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The sub-threshold doses of HGF and Dihexa combined, however, appeared to produce an effect similar to the saturating doses of HGF and Dihexa (p 0.05 by one-way ANOVA followed by Tukey post hoc test) as shown in The Morris water maze, a hippocampal-dependent spatial learning task requiring rats to locate a pedestal hidden beneath the surface of the water by orienting themselves to extra-maze cues was employed to evaluate the impact of the HGF antagonist, Hinge, on the pro-cognitive effects of Dihexa

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