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Additionally, NCOA4-ferritin heavy polypeptide 1-mediated iron metabolism disorder is related to retinal ganglion cell ferroptosis following pathologically high intraocular pressure injury [37]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Kaplan JR, Adams MR, Clarkson TB, Manuck SB, Shively CA, Williams JK

In general, Ca 2+ plays a central role in pollen germination and pollen tube growth, and an increase in cytosolic free calcium concentration ([Ca 2+ ]cyt) is a fundamental signaling transduction event (Steinhorst and Kudla, 2013

doi: 10.1016/j.anifeedsci.2004.06.002 [DOI] [Google Scholar] 29

With respect to the substantial similarity criteria, the applicant asserted that VANFLYTA is not substantially similar to other currently available technologies because VANFLYTA is the first drug to be expressly developed ( as a FLT3 inhibitor, not a multi-kinase inhibitor, and specifically optimized to inhibit the FLT3-ITD AML, thereby targeting the subpopulation of newly diagnosed patients with the worst prognosis (higher risk of relapse and worse overall survival)