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The severity of the disease depends on how much of the colon is involved

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However, this effect may be due to the large amount of cystine provided in the control conditions (208 M), as reduction of cystine levels in the medium did not impair growth but abolished intracellular cysteine and cystine levels (Extended Data Fig

Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines