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Across RCTs and syntheses, MI DCI improves ovulation, menstrual regularity, and surrogate ART outcomes (oocyte/embryo quality), with the 40:1 blend repeatedly associated with favorable endocrine and insulin-resistance profiles and lower gonadotropin requirements (161, 163)

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Preliminary fUS showed neurovascular coupling abnormalities, particularly in the anterior cingulate, potentially contributing to fatigue and depression