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Leading researchers have proposed that a central pathophysiological feature of these conditions is a severe "redox imbalance." When the body is initially exposed to a viral pathogen like SARS-CoV-2 or Epstein-Barr Virus (EBV), the immune system generates reactive oxygen species (ROS), or free radicals, as a weapon to destroy the invader

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GTP is constantly mobilized from the TCA cycle and directly from cytoplasmic ATP to meet free GTP energetic demands of various cellular functions

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Cataldo F., Lio D., Marino V., Scola L., Crivello A., Corazza G.R