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Figure 1 Lactate also plays a role in enhancing neuronal excitability in the prefrontal cortex by modulating BK channels, specifically reducing the level of fast afterhyperpolarization (fAHP) during action potentials

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doi: 10.1007/s43032-022-00859-5 264 SaugstadODKwintaPWollenEJBik-MultanowskiMMadetko-TalowskaAJagaMet al

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With both L-citrulline and arginine supplementation, adverse effects were rare and mild if they did occur