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In 2014, icotinib was approved to treat NSCLC patients with EGFR mutation regardless of past chemotherapy use.[6] The ICOGEN trial was a double-blind, head-to-head phase III study comparing icotinib with gefitinib in all-comers

Peripheral neuropathy, subacute combined degeneration of the spinal cord, or cognitive impairment indicate more advanced deficiency and generally require intensive treatment over extended periods

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Finally, the potential role of CD44, a surface receptor involved in cell-extracellular matrix interactions and migration, was examined

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7 Current treatments approved by the U.S