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DOX alters myocardial ETC gene expression and translation in vivo , reducing the redox cycle of the ETC complex I, and generates large amounts of ROS (56)

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Notably, RT-qPCR analysis showed a sharp increase in OCT4 mRNA expression, a marker of pluripotent stem cells and essential for TIC self-renewal [33], in the colonies formed in 3D gels relative to 2D culture conditions (Fig

Rather than viewing these as competing approaches, the evidence suggests they function best as complementary strategies in maintaining cellular redox balance

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Although the role of xCT in neurodegeneration and neuroprotection remains paradoxical, arsenic-induced upregulation suggests its indispensability for survival in stress condition