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In further embodiments, the invention encompasses a method of providing muscular therapy by administering a cation of Formula IA, wherein: the cation of Formula IA includes two or more non-hydrogen substituents at positions R 2 -R 8 , and wherein: R 5 is H or NH 2 , R 6 is H or F

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preparation of certain cations of the invention may occur via a one-pot procedure reported by Venkatesan et al

A: For chronic in vivo studies, daily administration of a specific 5-Amino-1MQ dosage is common to maintain consistent systemic exposure

NAD+ itself is the coenzyme that mitochondria burn through to make ATP and that sirtuins and DNA-repair enzymes consume as fuel