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TXNIP downregulates V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), a transcription factor to drive insulin expression, and thus negatively regulates insulin expression 25

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The inflammatory environment caused by obesity can induce insulin resistance, and further lead to other metabolic comorbidities

A recent 2023 meta-analysis highlighted the potential benefit of L-carnitine supplementation in the treatment of diabetes, showing promising results after analyzing 41 randomized clinical trials

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