Glutathione is a powerful antioxidant naturally produced in the liver and found in every cell of the human body
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control ) mL (30 g/ diosmin ) mL (60 g/ diosmin ) mL (30 g/ bromelain ) mL (60 g/ bromelain 8 10 12 14 Trolox equivalent [nmol/mg Hb] control (30 g/mL) diosmin (60 g/mL) diosmin (30 g/mL) bromelain (60 g/mL) bromelain 8 10 12 14 thiol group [nmol/mg Hb] *** * control ) mL (30 g/ diosmin ) mL(60 g/ diosmin ) mL (30 g/ bromelain ) mL(60 g/ bromelain 0.5 1.0 1.5 2.0 GSH [nmol/mg Hb] *** * control (30 g/mL) diosmin (60 g/mL) diosmin (30 g/mL) bromelain (60 g/mL) bromelain 800 900 1000 1100 1200 1300 amino group [nmol/mg Hb] Figure 2
This results in cleaved glutamate, cysteine and glycine while facilitating the transfer of -glutamyl moiety of GSH to either water (hydrolysis) or substrates such as peptides (transpeptidation)
Individual Sensitivities : Some individuals may have a heightened sensitivity to glutathione or its components, leading to allergic responses
Mechanisms involved in these effects have been attributed to mitochondrial dysfunction, inhibition of insulin signaling proteins, and negative modulation of the expression and translocation of the glucose transporter GLUT-4 [reviewed in (80)]