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Liposome-containing Hibiscus sabdariffa calyx extract formulations with increased antioxidant activity, improved dermal penetration and reduced dermal toxicity

When ferroptosis inhibitors such as GLS2 and erastin were applied to P53 wild-type cells, the cells exhibited upregulated PTGS2 gene expression and underwent ferroptosis, but when P53-deficient cells were induced with GLS2 and erastin, the PTGS2 gene expression level was unchanged and ferroptosis did not occur

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Meyer and Weihl, 2014), our findings underscore the relevance of this part of the lysosomal damage response for maintaining cellular homeostasis

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Mice received injections of Saline (Control group) or ovalbumin (OVA group) plus Complete Freunds Adjuvant administered subcutaneously on day 0 followed by OVA nasal instillations on days 21, 22 and 23