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Part of the cytoplasmic iron is involved in the normal metabolic activities of the cell, such as the activity of mitoferrin expressed in the mitochondrial inner membrane, which transports iron from the cytoplasm to the mitochondria to participate in the synthesis of heme and ironsulfur clusters (Philpott et al., 2017)

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The disease affects approximately 10% of the global population, with prevalence varying across regions due to differences in age, demographics, socioeconomic status, and access to healthcare (Rovin et al., 2024) and studies have consistently demonstrated a rising prevalence in both developed and developing countries

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Together, these changes suggest that Epitalon may support broader endocrine recalibration in aging organisms