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Vitamin B12 (cobalamin) is an essential nutrient that contributes to: Normal red blood cell formation Normal energy-yielding metabolism Normal function of the nervous system Normal psychological function Reduction of tiredness and fatigue Normal homocysteine metabolism These are authorised health claims for vitamin B12 in the UK

In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]