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Regulatory factors and signaling networks The Nrf2-ARE axis is a key signaling pathway regulating GSH synthesis and metabolism

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Nrf-2 has several beneficial roles and controls HO-1

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Particular attention will be paid to recent revelations on the activities and properties of these systems in animals that differ from those in other biological systems

Figure 3 Discussion Patients with moderate to severe TBI frequently experience persistent neurocognitive deficits, including short-term memory loss, executive dysfunction, and slowed cognitive processingsymptoms for which there are currently no FDA-approved treatments