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Cluster 1: Cellular Aging and Lifespan Regulation The most fundamental question in longevity genetics is how cells age and how the body's built-in aging mechanisms are regulated at the genetic level

Other ingredients Purified (deionized) water, aloe barbadensis (aloe vera) leaf gel, vegetable glycerin, prunus amygdalus dulcis (sweet almond) oil, extra virgin cocos nucifera (coconut) oil, simmondsia chinensis (jojoba) seed oil, glyceryl stearate, cetyl alcohol, stearic acid, beeswax, theobroma cacao (cocoa) seed butter, setria glutathione [as l-glutathione (oxidized)], phenoxyethanol, d-panthenol (vitamin b-5), allantoin, vitamin e (as d-alpha tocopheryl acetate), soy lecithin, potassium hydroxide, xanthan gum, origanum vulgare (oregano) leaf extract, thymus vulgaris (thyme) leaf extract, cinnamomum zeylanicum (cinnamon) bark extract, rosmarinus officinalis (rosemary) leaf extract, lavandula angustifolia (lavender) flower extract, citrus medica limonum (lemon) peel extract, mentha piperita (peppermint) leaf extract, olea europaea (olive) leaf extract

We validated the efficacy of the OligoScore strategy by querying it with genes differentially expressed in OPCs upon either a genetic ( Chd7 specific deletion in OPCs, (Marie et al., 2018)) or environmental perturbation (systemic injection of the pro-inflammatory cytokine IL1, (Schang et al., 2022))

The increased vascular permeability can be detected by measuring the extravasation of Evans blue dye

MAA, AJ, and AN collected the literature and wrote the different sections of manuscript

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