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Studies in animals and brain imaging in humans support the idea that similar brain circuits are affected in obesity and drug dependence, and dopamine-modulated reward circuits play a role in abnormal eating behaviors

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Both, the alpha-class related gst-32 and the GPX are implicated in the oxidative stress response by way of their GSH-dependent reduction of inorganic and organic peroxides or by their ability to eliminate secondary products of lipid peroxidation

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PC-CARs may also have an advantage over CARs that target membrane proteins in their ability to initiate a feed-forward loop of MHC upregulation and increased antigen density