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Emapalumab, approved by the FDA in 2018, is currently the only drug indicated for refractory or relapsed primary HLH in children (including neonates) and adults

Prieto-Hontoria et al

Unlike Erysipelatoclostridium , Lactobacillus was significantly and dramatically increased in 5A-1MQ-treated mice switched from WD to LD relative to their vehicle-treated counterparts and the LD control group

Treatment with maggot extract components resulted in a marked increase in the splenic Treg frequency and Foxp3 expression levels, concomitant with reduced expression of the GATA3 and RORt transcription factors