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Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material

Stanford is an AAALAC accredited institution

The hypoxic environment of the RA joint cavity and abnormal mitochondrial respiration of FLSs lead to an increase in glycolytic activity and Warburg effect (70)

There is some evidence for particular surgeries but with mixed outcomes

Interestingly, GLT1 which is located in astrocytes showed diminished functional activity that eventually decreased Glu clearance and increased epileptogenic foci (Peterson and Binder, 2019