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Interestingly, the weight loss effects were seen only in obese mice, with lean mice maintaining normal body weight, on average, even when exposed to fragment 176-191 [2]

Clinical trials have shown cardiovascular benefits with semaglutide in certain populations, though weight management remains the licensed indication in the UK

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We have also recently reviewed the preclinical and clinical aspects of NAD + -lowering drugs, with a special focus on NAMPT inhibitors, including their downstream effects and their optimization strategies [8]