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Conversely, higher FASN expression may lead to pathological angiogenesis through malonyl-CoA-mediated inhibition of mammalian target of rapamycin (mTOR) complex 1 (mTORC) signaling [109]

The accumulation of cytoplasmic TDP-43 aggregates is considered a late-stage event in neurodegeneration

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doi: 10.1210/en.2006-0782 93 BroglioFBensoACastiglioniCGotteroCProdamFDestefanisSet al

J Neurosci 25:108117 Henkel JS, Engelhardt JI, Sikls L et al (2004) Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue