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The appropriate concentration of the peptide, in the recommended dose, brings the expected therapeutic effect

Once mixed, some compounds may require refrigeration and have shorter usable timeframes

Inhibition of glutaminolysis with the glutamine analogue 6-Diazo-5-oxo-L-norleucine (DON) reduces immune-induced and autoimmune Tfh cellular and humoral responses, selectively targeting pathogenic auto-reactive immune cells while preserving the ability of Tfh to generate protective responses against pathogens (55)

2A and B) further confirmed the enhanced cellular uptake of CUR/miR155@DssD-Hb NPs in B16F10 and 4T1 cells facilitated by the ROS- and GSH-sensitive groups, exhibiting a 1.53- and 1.33-fold increase in cellular uptake compared to Cy5-miRNA@Lipo at 4 h

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Exemplary methods are described below