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J Neurosci 33:175186

The E155A mutation in cFSP1 (E156A in hFSP1) was reported to greatly impair the CoQ oxidoreductase activity and abolish the ability of ferroptosis inhibition 2

Further, an oxidative stress induced damage to the membrane of the cells which line the bile canaliculi (cells which are rich in GGT) may also contribute to the observed increase in the activity of this enzyme in plasma