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The value of selenium upon glutathione peroxidase 1 activity and oxidative stress mitigation in SARS-CoV-2 infection and COVID-19 disease has been clearly emphasized recently (Seale et al., 2020

Previous data demonstrates how IGF-1 can be an effective option in the treatment of this worldwide increasing condition

Nature 485:661665

In this regard, pyrimidine biosynthesis is also controlled downstream of mTORC1, via S6K1-mediated phosphorylation of CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, dihydroorotase), the rate-limiting enzyme catalyzing the first three steps in the pyrimidine biosynthesis pathway (Robitaille et al., 2013)