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Funding This work was supported by grants from the Canadian Institutes of Health Research (CIHR PJT155959, CIHR PJT168922 to ZJ), Canadian Natural Science and Engineering Research Council (NSERC RGPIN341498, RGPIN06295 to ZJ), and the Hospital for Sick Children Foundation (ZJ)

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Journal of neuroscience research 59:489-496

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Strengths and limitations To the best of our knowledge, this meta-analysis contains the largest number of studies to date, all of which are RCTs

Insulin & Glucose-Related Research Through NAD-related and metabolic-signaling pathways, 5-Amino-1MQ has been investigated in research involving: Glucose-regulation pathways Insulin-related metabolic models Mitochondrial glucose-metabolism investigations Cellular-energy homeostasis research Oxidative-stress and inflammatory-signaling pathways The interaction between NAD, SIRT1, and AMPK-related pathways remains an ongoing area of metabolic research interest