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[6] The structure of B 12 is based on a corrin ring, which is similar to the porphyrin ring found in heme

Still, it is a pharmacodynamically expected consequence of glucagon agonism and represents a meaningful differentiator from tirzepatide

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7 Similarly, in the CASTOR clinical trial, patients with relapsed or refractory multiple myeloma who received the combination of daratumumab with bortezomib and dexamethasone had significantly prolonged PFS relative to those who received bortezomib and dexamethasone alone

Use R53.1 when the record documents generalized weakness as a constitutional symptom without objective muscle weakness findings, or when the note supports debility/asthenia more than strength loss