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Isolation and characterization of a new pancreatic polypeptide hormone

The pharmacology in animal studies and early human studies supported this design: AOD-9604 stimulates lipolysis and inhibits lipogenesis through activation of beta-3 adrenergic receptors in adipose tissue, without producing the IGF-1 elevation or insulin resistance signal that exogenous GH produces

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Higher concentrations inhibited growth a biphasic response At 10 -8 M, follicle elongation was inhibited by 14.8 1.2% (2.3 0.18 mm)

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