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As the leading risk factor for the development of OA, aging can induce senescence-associated phenotypes in joints, such as increased levels of cytokines, MMPs, and ROS, and reduced expression of aggrecan and collagen II (191)

In some embodiments, pectins may be obtained from the dilute acid extract of the inner portion of the rind of citrus fruits or from apple pomace

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Hence, mitochondria are also the main source of cellular ROS (Sinha et al., 2013)

Phagocytosis in the brain: Homeostasis and disease

Independent adjudication of CT/MRI+/- angiography was the reference standard to establish LVO (anterior or posterior) or non-LVO