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Even though edavarone seems to be of value in neurological disorders, it has limited ability to cross the BBB

108 A meta-analysis of findings from four randomized controlled trials found tryptophan, at doses of 1 gram or more nightly, was particularly effective at improving indicators of sleep maintenance, such as decreasing wakefulness after sleep onset and increasing sleep efficiency

To summarize, thiols have found their use in treatment of a plethora of human diseases

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A deeper understanding of the three isoforms is without doubt needed for developing drugs or therapies targeting these enzymes

doi: 10.1002/(SICI)1098-108X(199703)21:2 3.0.CO;2-H