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Genotype and clinical phenotype in four patients with glutathione synthetase deficiency

Huichalaf C, Perfitt TL, Kuperman A, Gooch R, Kovi RC, Brenneman KA, Chen X, Hirenallur-Shanthappa D, Ma T, Assaf BT, Pardo I, Franks T, Monarski L, Cheng T-W, Le K, Su C, Somanathan S, Whiteley LO, Bulawa C, Pregel MJ, Martelli A

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190 These studies suggest that promoting ferroptosis is a promising strategy to overcome drug resistance in colon cancer patients

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For instance, the downregulation of GPx4 has been correlated with the manifestation of radiation injury in various tissues including the intestine, hemopoietic system, lung, cardiovascular system, ovary, and skin of the murine model though enhancing the ferroptosis mode of cell death [67]