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TAMs can assume two phenotypes in the TME: the M1 phenotype (classically activated) and the M2 phenotype (alternatively activated) [99]

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In this context, research strategies aimed at the selective inhibition of FOXO proteins including the use of peptide analogs such as FOXO4-DRI represent a promising approach for investigating the modulation of metabolic pathways, with potential relevance to diabetes-related complications

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