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Context-dependent stress signaling pathways activated by specific amino acid deprivation

Tirone, P.D

GraphPad Prism 9 (Version 9.5.1) (GraphPad Software, Boston, MA) was used for statistical analyses

Heterozygous tumor suppressor microenvironment in cancer development

In contrast, this area is a positively charged flat surface in GPx4 (Figure 4c) and has been considered to be involved in the efficient binding of complex lipid molecules at the active site 21

Next, we directly assessed whether the PVN Glu neurons contribute to these tonic currents in the DMV Ach neurons, specifically by ablating PVN Glu neurons based on infusion of a Cre-dependent genetically engineered caspase3 (AAV-DIO-taCaspase3) and AAV-DIO-EGFP viruses (or AAV-DIO-EGFP as a control) into the PVN, as well as FG injection into the small intestine of VgluT2-Cre mice (Supplementary Fig