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The insertion of both genes increased CAR-T cells proliferation and improved their ability to clear leukemia and solid tumors in vivo [118]

The latter event results in transactivation of genes coding for antioxidant and cytoprotective enzymes such as heme oxygenase (Hmox1), Nqo1, glutathione peroxidase (GPX2) and many others (reviewed in 73 , 74 ) (Figure 2A)

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[1] Cell Line:Senescent Leydig cells Concentration:25 mM Incubation Time:3 days Result:Reduced the viability of senescent as compared to normal TM3 Leydig cells