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In summary, low plasma selenium levels are associated with an increased risk of IBD

Glutathione S-transferases the first enzymatic step in mercapturic acid formation

Since ROS pathways are being considered new targets for OA treatment, the development of antioxidant therapy to counteract exacerbated oxidative stress is being continuously researched and enhanced in order to fortify the cellular defenses

Ann Thorac Surg 106(1):235-241, 2018

However, their therapeutic index is often narrowas exemplified by deferoxamine, which, despite being well-studied, is currently limited to treating acute iron poisoning and conditions involving chronic blood transfusions (e.g., thalassemia)