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Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain Palmitoylethanolamide (shortened to PEA) has anti-inflammatory and anti-hyperalgesic effects, due to the down-regulation of activation of mast cells Therapeutic potential of cannabinoids in trigeminal neuralgia there is growing evidence that cannabinoids may be effective in alleviating neuropathic pain and hyperalgesia [extreme pain sensitivity] via inhibiting neuronal transmission in pain pathways . All of the above can also improve mood and insomnia and reduce anxiety too

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