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1457-C ASSESSMENT OF REGIONAL IMPACT ON THE PHARMACOKINETICS OF VIR-2218 (BRII-835) IN SUBJECTS WITH CHRONIC HEPATITIS B VIRUS INFECTION Yali Zhu 1 , Sneha Gupta 2 , Chunming Li 1 , Chong Zhu 1 , Xiaofei Chen 1 , Weihong Liu 1 and Ji Ma 1 , (1)Brii Biosciences, (2)Vir Biotechnology, Inc Background: VIR-2218 (also referred as BRII-835) is an investigational, N-acetylgalactosamine (GalNAc)conjugated RNA interference (RNAi) therapeutic that targets a region of the hepatitis B virus (HBV) genome that is common to all HBV viral RNA transcripts

Positive regulators of catalase expression include, for example, Forkhead transcription factor (FOXO) family members and STAT3 transcription factors

3.4 Poor outcomes and immunosuppressive drugs administered during follow-up in patients with AAV During follow-up after diagnosis, among the 71 patients, 6 (8.5%) died, and 17, four, and one had ever experienced and suffered from ESKD, CVA, and ACS, respectively

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