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Its core pathophysiological characteristics are intricately intertwined with abnormal iron and lipid metabolism, oxidative stress, mitochondrial dysfunction, and neuroinflammation, driving the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) ( Figure 2 )

Recent findings have indicated that the inhibition of glutamine metabolism can lead to a suppression of cancer cell apoptosis, a process that is believed to be influenced by the level of reactive oxygen species (ROS) metabolism

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10.1038/s41422-023-00874-4 67 YuS.YeY.WurenT.YiH

Undermethylation Autism The Most Common Biotype One of the strongest biochemical patterns identified in ASD is undermethylation autism , present in more than half of all individuals on the spectrum