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Vitamin B12 Coenzymes Vitamin B12 has two active coenzyme forms, methylcobalamin and adenosylcobalamin

The retrospective, single-arm design without a control group limits causal inference, as placebo effects, regression to the mean, natural symptom fluctuation, and the standardized rehabilitation protocol may have contributed to observed improvements

Lancet 381(9871): 102936 pmid:23352552 9

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When paired with a healthy lifestyle or lipotropic injections, it may contribute to improved weight management