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Collectively, these data have identified a biological difference between children who are discordant for konzo and emphasize the role of oxidative stress in neglected motor system diseases, effectively opening new venues for research into potential disease mitigation strategies

many other glycosylation-prone targets have been identified that link nutrient availability with growth signaling 105,106,107,108,109,110 and this branch of research deserves more attention 111

Redox homeostasis is controlled by a variety of cell defense mechanisms, including three different superoxide dismutase (SOD1 in cells, SOD2 in mitochondria, SOD3), glutathione peroxidase (GPX), and signal pathways Nuclear factor erythroid 2-related factor 2 (NRF2)- Kelch-like ECH-associated protein 1(KEAP1) (71)

Lett Drug Des Discovery 16(10):11671174 Laun AS et al

10.2337/db15-1033 117

Stress increased depressive-like behavior, evaluated by longer immobility time in the forced swimming test, in addition to altering the expression of microRNAs and genes related to neurotransmission in different brain regions