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10.1016/j.phrs.2020.104784 Pharmacol Res

Throughout the study, safety assessments included physical examinations, vital sign measurements, electrocardiograms, laboratory testing, adverse event monitoring, and the administration of the Beck Scale for Suicidal Ideation

Furthermore, GW501516 inhibited ERK1/2 phosphorylation, which is involved in serine STAT3 phosphorylation, and increased AMP-activated protein kinase (AMPK) phosphorylation, which can inhibit STAT3 phosphorylation

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Engagement in regular physical exercise has been demonstrated to enhance endothelial function by promoting NO production, reducing oxidative stress, and stabilizing atherosclerotic plaques [30,31]