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Journal of Alzheimers Disease , 50 (2), 547-557

33,34,35,36,37 One study suggests that length of time from diagnosis of cognitive impairment is important for response rate, in that patients who had experienced symptoms for less than 12 months improved on B12, whilst those with symptoms for more than 12 months continued to decline

& Qiu, Y

doi:10.1002/14651858.CD011790.pub2

This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

While it's essential to consider financial factors, the benefits of maintaining optimal B12 levels far outweigh the price tag