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PD is mostly a sporadic disorder, but about 25% of the overall risk of the disease is due to genetic variation [6]

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By performing gene set enrichment analysis (GSEA) limited to human-derived reads, we confirmed the upregulation of senescence and IFN- response signatures on palbociclib treatment and their downregulation when compared with palbociclib + RSL3-treated mice (Fig

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Neuronal activity plays an active role in modulating microglial function, particularly in synapse pruning, which ultimately influences synaptic plasticity (Kim et al., 2020)